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Ischaemia and Shock Research

The research within the "Ischaemia and Shock Research Group" at the William Harvey Research Institute aims to gain a better understanding of disorders which are associated with a reduction in blood flow (ischaemia) to a specific organ. These disorders include myocardial infarction, stroke, circulatory shock and renal failure to name but a few. The goal of our research is to design novel therapies which reduce the detrimental consequences of ischaemia-reperfusion injury of e.g. the heart and, hence, to improve outcome. Novel therapies, which are currently under investigation, are e.g. (i) small, cell-membrane permeable radical scavengers, (ii) inhibitors of the activation of certain transcription factors which play a role in local and systemic inflammation (e.g. nuclear factor kappa-B), (iii) inhibitors of poly (ADP-ribose) synthetase (PARS). To gain a better insight into the above diseases, we use a great variety of scientific techniques from a variety of disciplines including pharmacology, biochemistry and molecular biology. If you are interested in our research, please contact c.thiemermann@mds.qmw.ac.uk

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