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Bone Metabolism Research

Our current research focuses on the role of nitric oxide in bone cell metabolism. For example, we are studying the effect of nitric oxide on apoptosis and also the role of oestrogen in inducing nitric oxide synthase (NOS) in bone cells.

We are collaborating extensively with Professor Nigel Benjamin (Clinical Pharmacology) on eNOS and nNOS knockouts as part of a collaboration with Dr Paul Huang in Harvard. We are investigating whether the urinary excretion of nitrate is derived from eNOS as part of the study of the role of NOS in cardiovascular disease. In a collaborative study with Professors Mone Zaidi and Malinski in Philadelphia, we are measuring directly with a microsensor the output of nitric oxide from bone cells. (i.macintyre@mds.qmw.ac.uk )

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